Apolipoprotein E is a apolipoprotein essential for the metabolism of triglyceride-rich lipoprotein constituents. it has been recognized for its importance in lipoprotein metabolism and cardiovascular disease.
ApoE genotyping may help guide lipid treatment when cardiovascular risks are high. It is used as an adjunct test to aid in the diagnosis of dementia and Alzheimer Disease, but an association has not been confirmed.
Abnormalities in the ApoE gene have been found in neonates with brain injuries and/or defects, and may increase the risk for Cerebral Palsy.
(Kuroda MM, Weck ME, Sarwark JF, Hamidulla A, Wainwrigt MS. Association of apolipoprotein E genotype and cerebral palsy in children.
Pediatrics 2007; 119(2): 306-313)