The general population is primarily exposed to palladium through dental alloys, jewelry, food and emissions from automobile catalytic converters.
Most commonly, sensitivity to Palladium is reported. People with nickel allergy are at risk,
Side-effects noted from medical or experimental uses of palladium preparations include fever, hemolysis, discoloration or necrosis at injection sites after subcutaneous injections and erythema and edema following topical application. A few case reports reported skin disorders in patients who had exposure to palladium-containing jewelry or unspecified sources.
WHO Environmental Health Criteria 226 2002